BioCentury
ARTICLE | Translation in Brief

Better glioma mouse models

CRISPR-edited mouse models for glioma

July 27, 2017 4:16 PM UTC

To accelerate the generation of glioma mouse models and find new oncogenic gene fusions, researchers from Memorial Sloan Kettering Cancer Center (MSKCC) have used CRISPR-based gene editing to produce mice in a method designed to be easily scalable and relevant for preclinical testing.

The goal was to create a system that could pick out oncogenic drivers from the thousands of gene fusions emerging from deep-sequencing studies in cancer, and test them against targeted therapies. ...