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Cutting cravings

Amygdala aims to treat addiction with ALDH2 inhibition

The former executive team from CV Therapeutics Inc. are treading familiar ground with an addiction program licensed from Gilead Sciences Inc. Newco Amygdala Neurosciences Inc. aims to develop ANS-6673 to treat substance abuse disorders currently underserved by therapeutics, including alcohol abuse and cocaine and opioid addiction.

The compound inhibits aldehyde dehydrogenase 2 family mitochondrial (ALDH2), a target CV Therapeutics was working on when it was acquired by Gilead in 2009. ANS-6637 builds upon that work but was discovered by Gilead.

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