BioCentury
ARTICLE | Distillery Therapeutics

Neurology

April 18, 2017 2:22 PM UTC

Mouse studies suggest promoting MSR-1 expression could help treat ischemic stroke. MSR-1 levels were higher in brain-derived myeloid cells from a mouse model of ischemic stroke than cells from normal mice. In the mouse model, the synthetic retinoic acid receptor α (RARA) agonist Amnolake tamibarotene - which promotes MSR-1 expression -- decreased neurological deficits and infarct volume in the brain and neurological deficits compared with vehicle. Next steps could include identifying and testing additional compounds that promote MSR-1 expression...