BioCentury
ARTICLE | Distillery Therapeutics

Cancer

March 30, 2017 5:37 PM UTC

Cell culture and mouse studies identified calcium channel T-type and potassium channel inhibitors that could help treat glioblastoma. Screening of a library of ion channel blockers against primary human glioblastoma cell lines identified a calcium channel T-type inhibitor and potassium channel inhibitor that inhibited growth with IC50 values of 0.07-0.36 nM and 0.40-0.57 µM, respectively. In a xenograft mouse model of glioblastoma, the calcium channel inhibitor increased survival and the potassium channel inhibitor decreased tumor growth and increased survival compared with vehicle. Next steps could include testing the channel blockers in other glioblastoma models...