PISA’s epigenetic tilt

Italian researchers have developed a platform for creating intracellular antibodies that selectively target acetylated versions of proteins without affecting their unmodified forms. The team believes the method can be modified to target proteins bearing other types of post-translational modifications, and plans to spin out a company to commercialize the technology.

Lead investigator Antonino Cattaneo told BioCentury that antibodies capable of distinguishing between modified and unmodified proteins could be important tools for studying epigenetic regulation and developing therapeutics. Cattaneo is a professor of physiology at Scuola Normale Superiore di Pisa...