Inflammation

INDICATION: Asthma

Cell culture and mouse studies suggest CHRNA7 agonists could help treat allergic asthma. In a mouse model of airway hyperresponsiveness, intranasal administration of a CHRNA7 agonist tool compound decreased airway resistance and dynamic compliance, eosinophil and total cell counts in bronchoalveolar lavage, airway wall thickness and the number of IL-5 and IL-13-producing type 2 innate lymphoid cells (ILC2s) in the lungs compared with vehicle. In an Alternaria alternata fungus-induced mouse model of allergic asthma, the agonist decreased airway resistance and the numbers of eosinophils and ILC2s in the lungs. Next steps could include testing CHRNA7 agonists in additional models of allergic asthma...