Neurology

Rat studies suggest GRIA antagonists or GABA A receptor agonists could help treat L-DOPA-induced dyskinesia in PD. In a rat model of L-DOPA-induced dyskinesia in PD, infusion into the primary motor cortex of a GRIA antagonist tool compound or a GABA A receptor agonist tool compound decreased abnormal involuntary movements compared with vehicle. Next steps include identifying other compounds that modulate neurotransmitter signaling in the primary motor cortex.

Eisai Co. Ltd. markets the GRIA antagonist Fycompa perampanel for epilepsy and seizures...