BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: TRAF2 and NCK interacting kinase (TNIK)

October 6, 2016 7:00 AM UTC

Cell culture and mouse studies suggest inhibiting TNIK could help treat colorectal cancer. In a human colorectal carcinoma cell line, the TNIK inhibitor NCB-0846 decreased tumor cell colony formation compared with vehicle or an inactive stereoisomer of the compound. In a xenograft mouse model of colorectal cancer, NCB-0846 decreased the number and size of tumors in the small intestine compared with vehicle. In a patient-derived xenograft mouse model of colorectal cancer, NCB-0846 decreased small intestine tumor growth. Next steps by Carna Biosciences Inc. could include testing the safety of NCB-0846...