Techniques: Tumor-selective delivery of antisense oligomers (antimiRs) against oncogenic microRNAs

TECHNOLOGY: Tumor-selective delivery of antisense oligomers (antimiRs) against oncogenic microRNAsMicroRNA-targeted antimiRs conjugated to a peptide with a low pH-induced transmembrane structure (pHLIP) and could help treat solid tumors. The pHLIP is designed to transport antimiRs across cell plasma membranes under the acidic conditions of the tumor microenvironment. In mice bearing microRNA-155 (miR-155)-dependent lymphomal tumors, pHLIP conjugated to an antimiR against miR-155 decreased tumor growth and increased survival compared with the unconjugated antimiR against miR-155 or a locked nucleic acid against miR-155. Next steps could include evaluating the pHLIP-conjugated antimiRs in additional tumor models.

DESCRIPTION: Tumor-selective delivery of antisense oligomers (antimiRs) against oncogenic microRNAs...