Therapeutics: Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

INDICATION: HypertensionMouse studies suggest inhibiting PGF could help treat hypertension. In mice, Pgf knockout decreased Ang2-induced hypertension and associated tissue pathology compared with wild-type Pgf expression. In mice, Pgf suppressed Timp3

TARGET/MARKER/PATHWAY: Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)...