BioCentury
ARTICLE | Distillery Therapeutics

Therapeutics: Guanine nucleotide binding protein (G protein) q polypeptide (GNAQ; G-ALPHA-q); calcineurin; transient receptor potential cation channel subfamily

May 21, 2015 7:00 AM UTC

Mouse studies suggest inhibiting GNAQ, calcineurin or TRPC6 could help treat focal segmental glomerulosclerosis (FSGS). In kidney podocytes, signaling between GNAQ and calcineurin activates TRPC6. In ...