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UnGluing safety concerns

Eli Lilly and Co. believes its first-in-clinic metabotropic glutamate receptor subtype 2/3 agonist, LY2140023, may address the safety concerns associated with marketed antipsychotics. The reason is the specificity for mGluR2/3 and no significant affinity for other glutamate receptor subtypes and transporters, or for nonglutamate receptors such as dopamine or serotonin.

Other glutamate receptors have been associated with toxicity,

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