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DNA vaccines: Beyond skin deep

The success of naked DNA vaccines hinges on their ability to generate a potent immune response against a specified antigen. Although most companies, including Vical Inc. and PowderJect Pharmaceuticals plc, deliver their DNA vaccines intramuscularly or intradermally, a study in mice suggests plasmid DNA injected into the lymphoid tissue was more efficient in inducing cytotoxic T lymphocyte (CTL) responses.

Researchers at University

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