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Doubling up on diabetes

Poxel's imeglimin acts on multiple organs with new MOA for diabetes combos

Poxel S.A. hopes imeglimin will become physicians' go-to oral therapy to combine with metformin in diabetes. Clinical data show it improves the activity of two affected organs, may be safer than targeted oral antidiabetics and has a unique mechanism of action that could provide efficacy benefits.

Three of the organ-specific defects in diabetes are excess glucose production by the liver, impaired glucose uptake in muscle and insufficient insulin secretion from the pancreas.

Last week, Poxel released top-line results from a 30-patient Phase II hyperglycemic clamp

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