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PeptiVir: Universal stabilization

PeptiVir developing flu vaccine using protein stabilization technology

July 16, 2012 7:00 AM UTC

Current peptide stabilization technologies use chemical linkers to keep peptides in their natural state, but in some cases these can cause autoimmune reactions. PeptiVir Inc. aims to avoid such effects by placing hydrophobic amino acids in specific locations within the core of its synthetic peptides to stabilize the compounds.

In the body, peptides are connected to other proteins that act as a stabilizing scaffold to maintain the peptide in a biologically active alpha helix conformation. The alpha helix regions allow the peptides to interact with other domains within the protein or with proteins involved in another complex...