Palm needs Alms

To continue development of lead compound ANA598, Anadys Pharmaceuticals Inc. will have to convince potential partners and investors that the efficacy data from a Phase Ib monotherapy trial are promising enough to outweigh concerns raised by a rash observed in healthy volunteers. The company believes the rash will prove manageable and that ANA598 could outperform its competitors as part of an HCV cocktail, but it doesn't have enough cash to complete a new trial.

Though the data were good, the Phase Ib study presented at the European Association for the Study of the Liver meeting in Copenhagen last month did not put the non-nucleoside NS5B polymerase inhibitor at the head of its class. In the placebo-controlled trial in 35 treatment-naïve patients, monotherapy with ANA598 given as twice-daily doses of 200, 400 and 800 mg produced median viral load reductions of 2.4 log10,

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