Big and small of DNA chemistries

Making pharmaceutically relevant chemical libraries remains an important bottleneck in drug discovery. Two DNA-directed chemistry companies that were founded in the past two years are creating very different kinds of libraries that serve different purposes.

Both Ensemble Discovery Corp. and Vipergen ApS are using DNA-based chemistry to catalyze reactions and synthesize compounds, which allows for more complex molecules to be assembled in less time and with greater control than conventional chemistry methods allow...