BioCentury
ARTICLE | Emerging Company Profile

Eyeing new antibiotics

Why SinSa's peptide antimicrobials could have low risk of resistance

February 23, 2015 8:00 AM UTC

Traditional antibiotics kill bacteria by inhibiting protein, DNA, or cell wall synthesis but require multiplying cells to be effective. SinSa Laboratories Inc.'s peptide antibiotics kill slow- and fast-growing bacteria by direct disruption of the cell membrane, and could have reduced risk of susceptibility to resistance mechanisms compared with existing antibiotics for antibiotic-resistant eye infections.

SinSa's antimicrobial peptides were created with its SpearHead technology, which incorporates positively charged amino acids and lipophilic groups to specifically disrupt negatively charged bacterial cell membranes regardless of their growth state...