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Engineering apoptosis

Cell death plays a role in many human diseases, and protein-protein interactions are the vessel through which most cellular signaling is transduced. Two groups of academic researchers now have addressed both issues, developing compounds that promote cell death by regulating protein-protein interactions.

The Bcl-2 family of proteins is composed of both pro- and anti-apoptotic proteins and as such has long been of therapeutic interest. All Bcl-2 family

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