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Catena: Breaking the chain

While antiangiogenics targeting VEGF have transformed treatment of some cancers and age-related macular degeneration, their use is associated with side effects including bleeding and gastrointestinal perforation. Catena Pharmaceuticals Inc. believes inhibiting signaling by lysophosphatidic acid, which has a different mechanism of action in angiogenesis as well as other biologic activity, could be safer than VEGF inhibition and may more specifically target some diseases.

Catena's lead molecule is VPC51299,

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