Double-barreled

Pharmacopeia Drug Discovery Inc. last week put its first home-grown compound into the clinic. The company says PS433540 is the first dual-acting angiotensin and endothelin receptor antagonist (DARA), but both targets are validated by marketed drugs. PCOP thinks that blocking them both will have a synergistic effect.

PS433540 started Phase I testing in hypertension and diabetic

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