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Trp-ing up cancer cells

Calcium channel blockers have been used for some time to target neurological and cardiovascular diseases, based on the potent role played by intracellular calcium (Ca2+) in signaling neurotransmission and muscular contraction. However, Dendreon Corp. has identified a trans-membrane voltage-gated calcium channel gene that is expressed on certain tumors, providing a new cancer target of sufficient interest to get Genentech Inc. on board as a partner.

DNDN (Seattle,

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