New Roles for Old Factor

Researchers at the University Medical Center Utrecht and Crossbeta Biosciences B.V. have linked high levels of activated Factor XII with amyloidosis, a metabolic disease that is characterized by misfolded protein aggregates.1 The company plans to use the discovery in two ways-developing diagnostics for amyloidosis and other protein-misfolding disorders and offering services to protein therapeutic developers to measure levels of potentially immunogenic misfolded proteins in their production batches.

Other companies and academics want to see additional mechanistic data demonstrating the

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