BioCentury
ARTICLE | Targets & Mechanisms

Joint attack

Targeting overactive fibroblasts could prevent joint damage in RA

May 28, 2015 7:00 AM UTC

A newly discovered pathway that causes joint erosion in rheumatoid arthritis could lead to a new class of therapies that act locally in cells of the synovial lining and avoid the drawbacks of immunosuppressants.

The pathway was identified by a group at the La Jolla Institute for Allergy & Immunology, which found that activation of a receptor phosphatase on synovial fibroblasts reduced the cells' pathological activity. ...