BioCentury
ARTICLE | Translation in Brief

Less is more

How losing one copy of a gene increases Heidelberg's ADC activity tenfold

May 7, 2015 7:00 AM UTC

A single copy deletion of RNA polymerase II in colorectal cancer makes the tumors 10 times more sensitive to Heidelberg Pharma's ADCs

Heidelberg Pharma's collaborators at the University of Texas MD Anderson Cancer Center have found a common genetic deletion in colorectal cancers that makes the tumors 10 times more sensitive to the company's antibody-drug conjugates (ADCs), thus widening the compounds' therapeutic index. Now the company wants to find other cancers that carry the same deletion. ...