BioCentury
ARTICLE | Translation in Brief

PK Gender Gap

Preclinical PK of PegIntron differs between male and female animals

March 26, 2015 7:00 AM UTC

A study that started out as a test of the lymphatic uptake of anticancer proteins evolved into a closer look at the effect of sex differences on cancer drug pharmacokinetics in animal models.

Last year, NIH began a push to encourage researchers to use male and female mice in preclinical studies with a $10.1 million project that would add sex as a variable in 82 existing projects. (See "Sex matters at the NIH." SciBX: Science-Business eXchange (Oct. 30, 2014))...