Therapeutics: Leucine-rich repeat containing 32 (LRRC32; GARP); transforming growth factor (TGF) β 1 (TGFB1)

In vitro and mouse studies suggest antibodies against the GARP-TGFB1 complex could help treat cancer by suppressing Treg cells. In co-cultures of human T helper (Th) and Treg cells, two mAbs that targ...