BioCentury
ARTICLE | Targets & Mechanisms

De-stressing glaucoma

June 5, 2014 7:00 AM UTC

Glucocorticoids are standard of care for a host of allergic and inflammatory eye conditions, but they elevate intraocular pressure about a third of the time and can result in secondary open-angle glaucoma. A chemical chaperone called sodium phenylbutyrate could eliminate that side effect, according to new research from The University of Iowa.1

The findings may hand a new indication to two companies-one Swedish, one Canadian-that market oral versions of phenylbutyrate (PBA) for other diseases...