BioCentury
ARTICLE | Targets & Mechanisms

PTSD: rewriting fearful memories

January 30, 2014 8:00 AM UTC

A Massachusetts Institute of Technology-led team has outlined a strategy for addressing the underlying causes of post-traumatic stress disorder.1 The approach centers on blocking histone deacetylase 2, which is the only class I histone deacetylase target with a growing body of evidence suggesting a role in learning and memory.

Future studies will need to identify a selective histone deacetylase 2 (HDAC2) inhibitor and determine its optimal human dosing to avoid unwanted effects on memory...