ARTICLE | Tools & Techniques
Family seeds
December 12, 2013 8:00 AM UTC
It has been long assumed that the specificity of microRNA inhibitors is determined by length-dogma held that anti-miRNAs should be more than 16 nucleotides and approximate the length of the actual miRNA targets. Now, an international team has in vivo proof of concept that using anti-miRNAs of only eight nucleotides in length does not compromise selectivity and provides a simple tool for blocking multiple miRNAs at once.1
The researchers are planning a Phase I trial following additional toxicology studies in animals...