Engaging drug discovery

Determining whether a compound binds its intended target is a fundamental question in drug discovery, but assays for measuring target engagement in vivo can be indirect and inconclusive. To remedy the situation, a Swedish group has modified an in vitro assay so that it can be applied to living systems.¹

The team founded Pelago Bioscience AB to optimize the assay, which they will provide as a service to aid drug discovery programs at client companies, and to adapt the assay for clinical applications...