Stabilizing RyR2

A group at Columbia University has found that preventing the leak of calcium ions from ryanodine receptors could help treat post-traumatic stress disorder, and a French team has found that the strategy could be effective for Alzheimer's disease.1,2 Based on these findings, Armgo Pharma Inc. is already pursuing the first indication and is considering testing its compounds in Alzheimer's disease.

Ryanodine receptor-operated calcium channels are one of the ways that calcium ions are released from the endoplasmic reticulum. Previous studies have implicated disruptions in calcium homeostasis in conditions ranging from cardiovascular disease to neurodegeneration.3,4

In 2004, Armgo was founded based on work from Columbia that showed the destabilization of ryanodine receptors in skeletal and cardiac muscle cells causes a calcium leak into

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