Memory is skin deep
A Harvard Medical School team has identified a T cell-based immune response in the skin that does a better job of protecting mice from some viral infections than circulating T cells.1 TremRx Inc. is using associated proprietary technology as the basis of a vaccine platform against infectious diseases and cancer.
"Conventional vaccines typically focus on the B cell arm of the immune system to create disease-fighting antibodies. The TremRx platform works to engage the T cell arm of the immune system through the generation of a newly discovered subpopulation of immune cells-the TRM cells-that reside in the skin, lung, gut and other epithelial tissues," said Thomas Kupper, professor of dermatology at Harvard Medical School. Kupper is also chair of dermatology at Brigham and Women's Hospital and the Dana-Farber Cancer Institute, and he is the scientific founder of TremRx.
Memory T cells reside in either blood or lymphoid tissue, where they are called T central memory (TCM) cells, or in epithelial tissues outside the blood and/or lymph