Difficile defense

A team led by The University of Texas Medical Branch has identified the nitrosylation of Clostridium difficile toxins as a host defense mechanism that reduces cellular damage caused by the pathogen. ¹ The researchers are now developing compounds that augment this response as an adjunct therapy to antibiotics.

C. difficile is an opportunistic bacterial pathogen that can cause severe diarrhea and pseudomembranous colitis, and it is a leading cause of hospital-acquired infections worldwide...