To include your compound in the COVID-19 Resource Center, submit it here.

Circle of protection against HIV

New in vitro research suggests that HIV infection can be prevented by inducing the endogenous production of θ-defensins, a class of cyclic antimicrobial peptides whose expression is thought to be blocked in the vast majority of humans.1 The use of aminoglycoside-based vaginal microbicides to induce the peptides is being tested for safety in macaques.

θ-Defensins are a class of cyclic 18-amino-acid peptides that contain 3 disulfide bonds and target HIV entry into cells. The compounds were first identified in rhesus macaques in 1999,2 but thus far nobody has found them to be expressed in humans. A 2002 study by a University of California, Los Angeles (UCLA) team found that humans have defensin-θ (DEFT) genes, but premature termination

Read the full 1163 word article

Trial Subscription

Get a two-week free trial subscription to BioCentury


Article Purchase

This article may not be distributed to non-subscribers