Transdermal transgene control

Researchers at the Swiss Federal Institute of Technology Zurich have demonstrated a way to control gene expression via transdermal use of a metabolite from apples.

The approach employs a gene expression control element that can be modulated using a skin-penetrating lotion containing the metabolite phloretin.¹ According to the Swizz Federal Institute of Technology Zurich (ETHZ) team, the phloretin-adjustable control element, dubbed PEACE, could enable a topical approach for modulating the expression of transgenes in subcutaneously implanted cells for therapeutic purposes...