BioCentury
ARTICLE | Targets & Mechanisms

Hormone attack on AD

June 17, 2010 7:00 AM UTC

A study by Arizona researchers provides a mechanistic explanation of how gonadal hormones may protect the brain from Alzheimer's disease, thus making a case for developing androgen receptor-activating strategies to treat AD.1

Although Ligand Pharmaceuticals Inc. alreadyhas a brain-selective androgen receptor modulator that has completed preclinical development for age-related muscle, bone and sexual indications, the challenge will be todesign a trial to catch AD sufficiently early so that treatment still could make a difference...