BioCentury
ARTICLE | Translation in Brief

Peptide guide to colon cancer

How a peptide targets cancer drugs to colon cancers

June 18, 2015 7:00 AM UTC

A group in Taiwan has identified a series of peptides that bind with high specificity to enolase 1 α (ENO1) on colorectal cancer (CRC) cells, and could improve tumor targeting of standard chemotherapies.

Conjugation of the ENO1-specific peptides to liposomal formulations of two commonly used cancer drugs improved the efficacy and safety profiles of the drugs in mouse models of CRC. Now the researchers are planning to use the peptides to develop colorectal tumor imaging diagnostics...