CrystalGenomics preclinical data

In a premalignant mouse prevention study, polmacoxib was effective in reducing polyp number and size in both the small and large intestines. In a premalignant mouse treatment study, polmacoxib led to significant growth suppression of established polyps in the small intestine and a reduction of polyp growth in the colon. Additionally, polmacoxib significantly reduced tumor growth in mouse xenograft models of colorectal cancer. Data were published in Investigational New Drugs. ...