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June 19, 1995 7:00 AM UTC

The South San Francisco company published the cloning, sequencing and tissue distribution of the gene for the bone remodeling enzyme cathepsin O2.

As reported in Biological Chemistry, Hoppe-Seyler, the distribution of the enzyme in osteoclasts, and its predominant presence in osteoclastomas, suggests a major role in bone resorption. Although CatO2 has been cloned previously, the extent of its role in bone remodeling hasn't been well understood. ...