CV Therapeutics, Genta data

Researchers working with antisense compounds demonstrated in rats that arteries injured by a balloon catheter stay open following infusion of two antisense molecules.

As published in the Proceedings of the National Academy of Sciences, the antisense molecules, aimed at two steps in the cell proliferation sequence, stopped the overgrowth of cells lining arteries. These cells typically multiply after angioplasty, blocking atherosclerotic blood vessels re-opened by the balloon. ...