ImmunoGen preclinical data

IMGN said low doses of the prodrug, a conjugate of the cytotoxic maytansinoid drug DM1 with a humanized monoclonal antibody against the CD56 tumor antigen, eradicated SCLC in a mouse xenograft model, with cures lasting ?200 days. In contrast, cisplatin, VP-16 or topotecan chemotherapy delayed tumor growth by 12-15 days. In a mouse model of metastatic SCLC, huN901-DM1 cured 6 of 10 animals, while untreated animals died within 50 days and cisplatin chemotherapy gave no survival benefit. ...