Myriad Genetics other research news
MYGN announced that its ProNet protein interaction technology to discover genes has revealed the roles of three genes in cancer. The MMSC1 gene appears to interact with the MMAC1 brain and prostate cancer gene identified previously by the company. The new gene is expected to provide a therapeutic target for small molecules. MYGN is collaborating with Schering-Plough Corp. to analyze the role of MMSC1.The CtIP gene has been linked to the BRCA1 gene in breast and ovarian cancer.
CtIP binds directly to the carboxy end of the BRCA1 gene, and links it to the E1A oncogene pathway. The mutations in BRCA1 that lead to increased risk of breast and ovarian cancer prevent CtIP from binding to the BRCA1 gene, suggesting this is the interaction necessary for the relevant tumor suppression, MYGN said. ...