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4:47 PM, Mar 06, 2018  |  BC Innovations | Distillery Therapeutics

Neurology

Cell culture and mouse studies suggest inhibiting necroptosis could help treat PD in patients harboring OPA1
mutations. In three neural progenitor cell lines derived from a patient harboring OPA1 mutations, a tool …
and survival compared with a tool compound that inhibits apoptosis. In a mouse model of OPA1-mutant …
12:00 AM, Nov 18, 2010  |  BC Innovations | Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Nerve damage Optic atrophy 1 (OPA1
Studies in cell culture suggest that increasing OPA1 signaling could help prevent nerve damage. In mouse …
cerebellar neurons, overexpression of the GTPase Opa1 decreased Nmda-induced cell death compared with that in nonoverexpressing …