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8 results
12:00 AM, May 26, 2016  |  BC Innovations | Distillery Therapeutics

Therapeutics: Angiopoietin 2 (ANG2; ANGPT2); tyrosine kinase receptor 2 (Tie2)

Infectious disease INDICATION: Sepsis Cell culture and mouse studies suggest an antibody that binds ANG2 and …
In human umbilical vein endothelial cells and human lung endothelial cells, a mAb that bound ANG2
without disrupting the ANG2/Tie2 interaction increased Tie2 phosphorylation compared with an antibody that antagonized ANG2. In …
9:03 AM, Dec 18, 2014  |  BC Innovations | Distillery Therapeutics

Therapeutics: Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

and associated tissue pathology compared with wild-type Pgf expression. In mice, Pgf suppressed Timp3 TARGET/MARKER/PATHWAY: Angiopoietin 2
ANG2 ; ANGPT2 ); placental growth factor (PGF; PlGF ); tissue inhibitor of metalloproteinases 3 …
12:00 AM, Aug 08, 2013  |  BC Innovations | Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease Sepsis Angiopoietin 2 (ANG2; ANGPT2) Mouse …
studies suggest inhibiting ANG2 could help treat sepsis. ANG2 is upregulated during sepsis. In mice, endothelium-specific …
ANG2 overexpression increased microvascular disturbances, hypotension and dilatory cardiomyopathy compared with normal expression. In a mouse …
12:00 AM, Aug 13, 2009  |  BC Innovations | Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Parkinson's disease (PD) Angiopoietin 2 (ANG2; ANGPT2
delta-like 4 (Dll4) A study in monkeys and rodents suggests that two endogenous ligands-Ang2 and Dll4-could …
be useful for treating PD. In a rat model of PD, intracerebroventricular injections of Ang2 or …
12:00 AM, May 21, 2009  |  BC Innovations | Distillery Therapeutics

Indication: Cardiovascular disease

in response to reactive oxygen species and promotes inflammation. Mice lacking Cypa were protected from angiopoietin 2
Ang2)-induced abdominal aortic aneurysm formation compared with wild-type mice. Mice lacking Cypa also had less inflammatory …
12:00 AM, Oct 30, 2008  |  BC Innovations | Distillery Therapeutics

Indication: Infectious disease

in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Infectious disease Malaria Angiopoietin 2
Ang2) Studies using human plasma suggest that antagonizing Ang2 could be useful for treating malaria. In …
patients with severe falciparum malaria, higher Ang2 concentrations were associated with greater parasite biomass and patient …
12:00 AM, Oct 23, 2008  |  BC Innovations | Distillery Therapeutics

This Week in Therapeutics

Summary Licensing status Publication and contact information Neurology Neurology; inflammation Tumor necrosis factor-a (TNF-a); IL-1b; angiopoietin 2
ng2) Studies in mice suggest that antagonizing Ang2 in the vasculature could help treat neuroinflammatory disorders …
the cerebral cortex than tissue from mice that received saline. Leukocyte infiltration was mediated by Ang2
12:00 AM, Sep 18, 2008  |  BC Innovations | Distillery Therapeutics

This Week in Therapeutics

the apelin peptide could be useful for treating atherosclerosis. In ApoE-deficient mice, apelin suppressed the angiopoietin 2
Ang2)-mediated induction of atherosclerosis and the formation of abdominal aortic aneurysms. In a mouse vein graft …
model, apelin inhibited Ang2-mediated increases in neointimal formation. Next steps include improving the pharmacokinetic properties of …