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12:05 PM, Jun 20, 2018  |  BC Innovations | Distillery Therapeutics

Endocrine/Metabolic

INDICATION: Diabetes Patient sample and mouse studies suggest inhibiting ANGPTL4 could help treat insulin resistance. In …
non-diabetic individuals, a loss-of-function mutation in ANGPTL4 was associated with low levels of fasting blood glucose …
and high insulin sensitivity. In a high-fat diet-induced mouse model of insulin resistance, systemic ANGPTL4 knockout …
12:00 AM, Jun 18, 2015  |  BC Innovations | Distillery Therapeutics

Therapeutics: Angiopoietin-like 4 (ANGPTL4)

Ophthalmic disease INDICATION: Diabetic retinopathy In vitro studies suggest inhibiting ANGPTL4 could help treat proliferative diabetic …
retinopathy (PDR). ANGPTL4 levels were higher in aqueous fluid from the eyes of PDR patients than …
microvascular endothelial cell-based angiogenesis assay, pretreatment of aqueous fluid samples from PDR patients with an anti-ANGPTL4
12:00 AM, Jan 30, 2014  |  BC Innovations | Distillery Therapeutics

Indication: Renal disease

in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Renal disease Renal disease Angiopoietin-like 4
ANGPTL4); integrin aVb5 Rat studies suggest ANGPTL4 variants that selectively bind to integrin aVb5 could help …
have not been functionally linked. In rat models of a precursor phase of nephrotic syndrome, Angptl4
12:00 AM, Sep 19, 2013  |  BC Innovations | Distillery Therapeutics

Indication: Ophthalmic disease

Summary Licensing status Publication and contact information Ophthalmic disease Diabetic retinopathy; diabetic macular edema (DME) Angiopoietin-like 4
ANGPTL4) Mouse and cell culture studies suggest inhibiting ANGPTL4 could help treat ischemic retinopathies such as …
oxygen-induced retinopathy, hypoxic retinal Müller cells were shown to promote vascular permeability by upregulation of Angptl4
12:00 AM, Mar 31, 2011  |  BC Innovations | Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Angiopoietin-like 4
ANGPTL4) In vitro and mouse studies suggest that inhibiting ANGPTL4 could help treat cancer. In human …
tumor tissue arrays, ANGPTL4 expression was greater than that in corresponding normal tissues. In mice with …
12:00 AM, Aug 19, 2010  |  BC Innovations | Distillery Therapeutics

Indication: Cancer

Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cancer Kaposi's sarcoma (KS) Angiopoietin-like 4 (ANGPTL4
In vitro and mouse studies suggest that inhibiting ANGPTL4 could help treat KS. In experimental and …
patient KS lesions, ANGPTL4 levels were greater within the lesions than outside them. In a KS …
12:00 AM, Jan 15, 2009  |  BC Innovations | Distillery Therapeutics

Indication: Diagnostics

Summary Licensing status Publication and contact information Diagnostics Metabolic disease; atherosclerosis Angiopoietin-like 3 (ANGPTL3); ^ ANGPTL4
levels and decreased risk for metabolic disorders and atherosclerosis. Patients with loss-of-function mutations in ANGPTL3, ANGPTL4
triglyceride levels than control individuals. In human embryonic kidney cells, loss-of-function mutations in ANGPTL3 or ANGPTL4
12:00 AM, May 01, 2008  |  BC Innovations | Distillery Therapeutics

This Week in Therapeutics

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Transforming growth factor-b (TGF-b); angiopoietin-like 4
Angptl4) Studies in mice and cell culture suggest that blocking TGF-b signaling could be a strategy …
mice (p …