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2:13 PM, Apr 17, 2018  |  BC Innovations | Distillery Techniques

Disease models; drug properties

and express high levels of mRNA for cytochrome P450 3A4 (CYP3A4), the tight junction protein occludin
OCLN), and the ATP-binding cassette sub-family B member 1 (ABCB1; MDR1; PGP; CD243) efflux pump. In …
11:00 AM, Aug 16, 2017  |  BC Innovations | Distillery Techniques

Disease models

spheroids exhibited BBB features, including high expression of tight junction proteins claudin 5 (CLDN5) and occludin
OCLN) , VEGF -dependent permeability and high expression of the ATP-binding cassette sub-family B member 1 …
12:00 AM, Sep 05, 2013  |  BC Innovations | Distillery Techniques

Technology: Disease models

to help evaluate antiviral drug candidates. Transgenic mice with stable expression of human CD81 and occludin
OCLN) in the liver supported HCV entry, but infection was limited to a single cycle. In …
available to the research community. SciBX 6(34); doi:10.1038/scibx.2013.941 Published online Sept. 5, 2013 Use of OCLN
12:00 AM, Jun 16, 2011  |  BC Innovations | Distillery Techniques

Technology: Disease models

expression of human CD81, scavenger receptor class B member 1 (SCARB1), claudin 1 (CLDN1) and occludin
OCLN) allowed a single cycle of HCV infection. In the same mice, immunization with a vaccinia …
compared with no immunization. Next steps include testing transgenic mice with only human CD81 and OCLN