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    E.g., 2018-02-22

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12:45 PM, Feb 21, 2018  |  BC Extra | Politics & Policy

India names new drugs controller general

The Government of India's Ministry of Health and Family Welfare appointed S. Eswara Reddy as drugs controller general of India for three months, or until a permanent appointment is found. Reddy, who was joint drug...
12:06 PM, Feb 21, 2018  |  BC Extra | Clinical News

AbbVie's elagolix meets in Phase III for uterine fibroids

AbbVie Inc. (NYSE:ABBV) said elagolix (ABT-620) met the primary and all ranked secondary endpoints in the Phase III ELARIS UF-I (M12-815) trial to treat uterine fibroids. The trial is the first of two replicate Phase...
11:20 AM, Feb 21, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Nanoparticles DNA-based nucleolin-targeting nanoparticles could be used to deliver therapies for cancer. The nanoparticles consist of DNA tubes with an inner surface conjugated to therapeutic cargos and an outer surface linked to aptamers that bind...
11:20 AM, Feb 21, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Nanoparticles Photo-activated, tumor-targeted nanoparticles could be used to deliver cancer therapies. The nanoparticles consist of an internal core of dodecyne lipids to enhance stability and enable cancer cell endocytosis, conjugated to an outer layer of...
11:19 AM, Feb 21, 2018  |  BC Innovations | Distillery Techniques

Chemistry

TECHNOLOGY: Tool compounds A peptidomimetic compound that inhibits the DCUND1-UBE2M interaction and neddylation of cullin 3 (CUL3) could be used to probe the role of the CUL3/DCN1 cullin-RING ligase complex in squamous cell lung carcinoma. Computational...
11:18 AM, Feb 21, 2018  |  BC Innovations | Distillery Techniques

Drug delivery

TECHNOLOGY: Nanoparticles Laser-activated, silica-carbon-based nanoparticles could enhance the effectiveness of chemotherapies delivered to multidrug-resistant (MDR) tumors. The nanoparticles consist of a hybrid silica-carbon core with a lipid membrane coating; upon exposure to near-infrared (NIR) laser radiation,...
11:18 AM, Feb 21, 2018  |  BC Innovations | Distillery Techniques

Biomarkers

TECHNOLOGY: Plasma markers The pre-HIV infection fraction of CD4+ T cells expressing integrin α4β7 could help predict susceptibility to HIV infection. In 70 of 206 at-risk women from South Africa and Kenya who contracted HIV via...
11:17 AM, Feb 21, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Prostate cancer Mouse studies suggest inhibiting BMI1 could help treat castration-resistant prostate cancer (CRPC). In a mouse model of CRPC, a tool compound BMI1 inhibitor decreased tumor growth compared with vehicle. Also in the...
11:16 AM, Feb 21, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer Mouse studies suggest depleting asparagine with l-asparaginase or ASNS inhibition could help treat metastatic breast cancer. In an allogeneic mouse model of metastatic breast cancer, shRNA targeting ASNS decreased the number of lung...
11:13 AM, Feb 21, 2018  |  BC Innovations | Distillery Therapeutics

Cancer

INDICATION: Breast cancer; colorectal cancer Mouse studies suggest combining inhibitors of TGFβ signaling with anti-PD-L1 therapies could help treat breast and colorectal cancers. In a mouse model of breast cancer in which T cells cannot penetrate...

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