Bone-free BMP

Thrasos Innovation Inc. believes its selective bone morphogenetic protein receptor activators will work for kidney disease because they trigger the BMP pathway's anti-inflammatory, anti-apoptotic and antifibrotic properties, but not its osteogenic properties.

BMP has been in development for kidney disease at least since the mid-'90s. In 1996, Creative BioMolecules Inc., now Curis Inc., presented data showing that bone morphogenetic protein 7 (BMP7; OP-1) protected against kidney damage in animal models of chronic and acute renal failure...