BioCentury
ARTICLE | Distillery Therapeutics

Induction of NFE2L2 activity for Alzheimer's disease

June 26, 2019 11:28 PM UTC

INDICATION: Alzheimer's disease (AD)

Inducers of NFE2L2 activity could help treat AD. Postmortem brain tissue from seven AD patients had lower NFE2L2 protein levels than tissue from seven control donors, and low NFE2L2 transcript levels were associated with larger β amyloid plaques. In mice with AD, sulforaphane -- an organic isothiocyanate found in cruciferous vegetables that induces NFE2L2 -- improved performance in behavioral tests of learning and memory and decreased levels of neurotoxic β amyloid and phosphorylated tau in brain tissue...